General Information

  • ID:  hor005073
  • Uniprot ID:  B3A0J4
  • Protein name:  CAPA-Pyrokinin
  • Gene name:  NA
  • Organism:  Pachyphasma brandbergense (Gladiator) (Heel-walker)
  • Family:  pyrokinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pachyphasma (genus), Mantophasmatidae (family), Mantophasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NSGGGEGSGMWFGPRL
  • Length:  16(1-16)
  • Propeptide:  NSGGGEGSGMWFGPRL
  • Signal peptide:  NA
  • Modification:  T16 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-B3A0J4-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-B3A0J4-F1.pdbhor005073_AF2.pdbhor005073_ESM.pdb

Physical Information

Mass: 187647 Formula: C69H101N21O22S
Absent amino acids: ACDHIKQTVY Common amino acids: G
pI: 6.41 Basic residues: 1
Polar residues: 9 Hydrophobic residues: 3
Hydrophobicity: -59.38 Boman Index: -1695
Half-Life / Aliphatic Index: 1.4 hour Aliphatic Index: 24.38
Instability Index: 1481.25 Extinction Coefficient cystines: 5500
Absorbance 280nm: 366.67

Literature

  • PubMed ID:  22508719
  • Title:  Peptidomics-based phylogeny and biogeography of Mantophasmatodea (Hexapoda).